RECOMMENDATIONS FOR TREATING BDD WITH AN SRI: DON’T GIVE UP ON AN SRI UNTIL YOU’VE TRIED IT FOR 12 TO 16 WEEKS, WHILE REACHING A HIGH ENOUGH DOSE
RECOMMENDATIONS FOR TREATING BDD WITH AN SRI: DON’T GIVE UP ON AN SRI UNTIL YOU’VE TRIED IT FOR 12 TO 16 WEEKS, WHILE REACHING A HIGH ENOUGH DOSEIt’s also important to try the SRI for a long enough time. Taking the SRI for 12 to 16 weeks, and reaching a high dose (unless a lower dose works for you) for at least 3 of those weeks is called an “adequate” trial. If you don’t take a high enough dose, or if you don’t try it for long enough, the SRI trial is considered “inadequate.” In other words, it may not be sufficient to successfully treat BDD.In most published BDD studies and in my clinical practice, people needed to take an SRI, on average, for 6 to 9 weeks before BDD symptoms substantially improved. In my fluoxetine (Prozac) study, two thirds of people substantially improved (i.e., “responded”) between the 4th and 11th week of treatment. In my fluvoxamine (Luvox) study, two thirds improved between the 3rd and 10th week of treatment. However, in my citalopram (Celexa) and escitalopram (Lexapro) studies, people responded to the medicine, on average, after only 4 to 5 weeks (two thirds responded between weeks 1-2 and 7-8). So some people respond to an SRI within several weeks, whereas others have to try it for as long as 12 weeks—or occasionally even 16 weeks—before they respond. This means you’ll need to be patient and wait for the medicine to work. But don’t get discouraged: it often does work!It’s worth emphasizing that these numbers and recommendations are based on studies that increased the SRI dose, and reached the high end of the dosing range, fairly quickly (see the examples above). If you raise your SRI dose more slowlv (i.e.. if vou take more than 9 weeks or so to reach the maximum recommended dose), you may need more than 12 to 16 weeks to get better. If you haven’t gotten to a high enough dose by week 12 to 16, it’s usually advisable to try to raise your dose at that point to see if a higher dose works better than a lower dose. But if you’ve already reached the highest dose recommended by the pharmaceutical company, or the highest dose you can tolerate, by 12 to 16 weeks—and if you’ve been on that highest dose for at least 3 weeks—then it’s probably best to make a change by switching to another SRI or adding another medicine to the SRI. I often see patients who’ve tried lots of SRIs without getting better. A common problem is that they tried the SRI for too brief a time (e.g., only 4 to 8 weeks). In my fluoxetine study, nearly half of the people who eventually responded to the medication still hadn’t responded by the 8th week of treatment. This was the case for one third of the people in my fluvoxamine study. These people generally responded between weeks 8 and 12 of treatment. In addition, many people I’ve seen who didn’t respond to a past SRI never reached a high enough dose. Often such patients have been diagnosed with depression while their BDD was missed. Because their BDD wasn’t recognized or diagnosed, it wasn’t effectively treated. For many, depression didn’t improve either.*258\204\8*